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Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development

-Adrenergic Receptor Sensitivity: Potential secondary up-regulation of -AR expression, enhancing response to adrenergic stimuli

For people with low-normal B12 levels who feel fatigue or brain fog, a course can help while the root cause is investigated

Herrmann W, Schorr H, Obeid R, Geisel J

It is important to talk to your doctor or nurse about the risks and benefits of vitamin B12 injections before receiving them.

Reviewer 2 In a similar paper Tamoxifen Activation of Cre-Recombinase Has No Persisting Effects on Adult Neurogenesis or Learning and Anxiety by Rotheneichner et al