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The HPV vaccine currently used in the United States, Gardasil 9, can protect against nine of the cancer-causing HPV strains

We explored this by analysing the expression pattern of Bim and PUMA , the downstream effectors of the Bcl-2 family

Bifidobacterium can also effectively prevent the translocation of bacterial derivatives, such as lipopolysaccharide, to the liver via the portal vein, thereby alleviating hepatic inflammatory responses and endoplasmic reticulum stress [39]

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This allosteric targeting approach can effectively avoid pseudotargeting or loss of target, and the plug-and-play targeting moieties effectively improved the biocompatibility and stability of the formulation and showed good universality for various lipid-based carriers and membrane receptors