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10.1242/bio.042655 Biol

Cedrol alleviates inflammation-induced barrier dysfunction by promoting ATP synthesis and enhancing tight junction protein mRNA expression [383]

72 The peroxisome proliferator-activated receptor(PPAR)/liver X receptor(LXR-) signaling pathway is key to the regulation of inflammation and oxidative stress in vivo, and activation of this pathway can effectively inhibit the release of inflammatory mediators and ROS

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Furthermore, descending inhibitory pathways, which modulate the visceral pain signal by releasing neurotransmitters such as opioids, noradrenaline, dopamine and 5-HT [94], are down-regulated in IBS patients as indicated by an increased somatic sensitivity [95]

Editors note: This article was originally published Oct