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Furthermore, defects in the glycine conjugation pathway in individuals with obesity are a relatively recent discovery 11,21 , and it is unknown whether glycine supplementation in humans can improve the formation and excretion of acylglycines

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Delgadillo-Puga C, Snchez-Castillo D, Cario-Cervantes Y, Torre-Villalvazo I, Tovar-Palacio C, Vsquez-Reyes S, Furuzawa-Carballeda J, Acevedo-Carabantes J, Camacho-Corona M, Guzmn-Mar J, Cisneros-Zevallos L, Tovar A, Rebollar-Vega R, Hernndez-Montes G, Ulloa-Aguirre A, Palacios-Gonzlez B, Noriega L

However, most researchers consider it an autoimmune disease whose pathogenesis is linked to genetic susceptibility, environmental factors, immune system dysregulation, infections, and the gut microbiota [10, 11]

These shifts are rarely dramatic enough to prompt a doctor's visit but they are consistent, and they are physiological