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196 Due to its poor bioavailability, however, NAC must be administered in fairly high doses and requires a long treatment time in patients with severe APAP overdose, thereby increasing the risk of an anaphylactoid reaction (i.e., nonimmunologic anaphylaxis), fluid overload, and high fluid osmolarity

This can only be achieved through stable chemistry methods and crafting liposomes that are small enough to easily diffuse through cell membranes

Moreover, it is less toxic compared to 5-Aza and DAC, enabling oral administration

Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation

Cell Mol Immunol (2018) 15:90716