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Thus, both TRPM2 and TRPM7 are involved in accidental necrosis by participating in the NVI induction and in the following RVD dysfunction, thus attaining persistent cell swelling due to the continuous inflows of Na + , Cl , and osmotically obliged water (Figure 7)

Prosthetic group A small molecule that is covalently bound to a protein and is essential for its function

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These results suggest that children and adolescents who live in hypoxic environments lack the adaptive mechanisms of their adult counterparts

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