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When B12 levels drop, it can lead to fatigue, cognitive difficulties, mood imbalances, nerve problems, and even anemia

Damage can occur from many sources, including: Diabetes A leading cause of neuropathy Infections Such as Lyme disease or shingles Auto-immune diseases Conditions like lupus and rheumatoid arthritis can attack the peripheral nerves Chemotherapy Some cancer treatments can cause nerve damage Nutritional deficiencies namely Vitamin B12 So now we know a little more about neuropathy and its causes lets move on to B12

Following endocytosis, the HoloTC complex is degraded in lysosomes and free B12 is released into the cytoplasm, via CblF (Rutsch et al., 2009) and CblJ ( This free cytoplasmic B12 undergoes a series of intracellular transport and modifications to enable two core enzymatic reactions: 1) adenosyl-B12 acts as a co-factor for the enzyme methylmalonyl-coA mutase that catalyzes the conversion of methylmalonyl-coA to succinyl-coA, thereby enabling restoration of tricarboxylic acid (TCA) cycle intermediates and 2) methyl-B12 enables methionine synthase in the re-methylation of homocysteine to methionine using methyl-tetrahydrofolate (MTHF) as a methyl donor, thereby enabling the vital biochemical pathways of the folate cycle and methionine cycle, facilitating the downstream synthesis of important compounds like DNA and RNA (Figure 2)

found that D614G can alter the fitness and enhance the replication of SARS-CoV-2 in the lungs

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This is a unique cryodesiccation (dehydration) process, where the peptides are frozen and then subjected to a low pressure vacuum