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Measurement of SOD activity SOD activity was detected via a total SOD activity detection kit (S0101, Beyotime, China) by the reaction of NBT (nitro blue tetrazolium) with two molecules of superoxide anion to yield a blue-colored chromogen

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Current Pharmaceutical Design, 19(1), 126-132

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Methods: This study investigates (i) the enzymatic functions of CD38, (ii) the in vitro effects of DARA and ISA on CD38_mediated NAD + degradation in primary MM cells and a representative MM cell line, and (iii) the in vivo dynamics of ADO and its metabolite inosine (INO) in BM and peripheral blood (PB) plasma from MM patients receiving DARA monotherapy

These sdAbs offer several advantages, including small size, high stability, remarkable specificity and affinity for the target antigen, and the ability to recognize hidden epitopes