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The cycling approach most protocols recommend partly addresses these uncertainties

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This mismatch explains why short clinical studies often overestimate long-term real-world performance

Histological evaluation of colitis Colon tissue segments (0.5 cm) were washed with PBS and fixed in paraformaldehyde for 48 h before being embedded in paraffin and cut into 4 m thick sections for further analysis

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Additional sources were identified through manual screening of the references of key articles to ensure comprehensive coverage of the topic