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Paradoxically, while this should acidify the cytosol (intracellular pH, pHi), neoplastic cells maintain pHi within 7.17.7 (versus ~7.2 in normal cells) through adaptive mechanisms: (i) upregulated SLC16A3 (encoding MCT4) extrudes lactate/H +

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doi: 10.1007/978-981-10-9029-5_7 100 SunY.-L.HongS.-K

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