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ROS can directly damage biological structures, including lipids, proteins, and DNA, contributing to cell death, necrosis, and apoptosis (Juan et al., 2021)

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tacrolimus trough levels were not measured

doi: 10.1016/j.trecan.2023.04.012 57 LiuJ.-F.GuoD.KangE.-M.WangY.-S.GaoX.-Z.CongH.-Y.et al

Indications Skin radiance and pigmentation support Melasma adjunct Oxidative stress conditions Diabetic neuropathy (ALA component) Anti-ageing support Mechanism of Action L-Glutathione is the body's principal intracellular antioxidant

While several studies examined GPx activity [63, 71, 72, 74, 81, 83, 84] or its polymorphisms [94, 95], only one examined glutathione reductase or glutathione-S-transferase activity [85]