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Additionally, Karin et al.'s research indicates that the activation of T-cells hinges on glycolysis that perpetually generates lactate, and the accumulation of lactate in cells throws T-cells' metabolism into disorder and retards their activation [99]

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Disrupted BBB and the blood-cerebrospinal fluid barrier are evident in both sporadic and familial ALS, occurring before the onset of motor neuron degeneration (Fig

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