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During these processes, GSH is converted into its oxidized form, glutathione disulfide (GSSG)

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In HCC cells, NRF2 activation transcriptionally represses the expression of selenoprotein P (SELENOP), the main protein responsible for transporting selenium out of the cell [108]

Response-Based Approach: Treatment duration is individualized based on objective measurements including body composition analysis (DEXA scan, bioimpedance), waist circumference, metabolic markers, and subjective response

Excessive reduction of ROS may impair these fundamental physiological functions, potentially weakening host defense mechanisms and disrupting normal skin repair processes