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In the elderly, the gut microbiota displays diminished bacterial diversity, alterations in dominant species, a reduction of advantageous microorganisms, elevated presence of facultative anaerobic bacteria, and a decline in overall short chain fatty acid availability 36

193 The dense and cross-linked collagen networks, together with elevated solid stress, create a rigid and heterogeneous structure that restricts convective transport and molecular diffusion within the tumor microenvironment

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Goel A, Goel AK, Kumar A