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Ultimately, we anticipate that the continued development of precise and effective senotherapeutic interventions will lead to the targeted elimination of senescent cells, their detrimental SASP, and improved health outcomes in age-related diseases such as AD

This study shows that age-dependent metabolic change, that is, methylmalonic acid accumulation in the blood, promotes cancer progression by inducing Sox4

DOI:10.1016/j.jprot.2013.01.004 54

The erythrocyte pellet was washed and resuspended in isotonic phosphate buffer to a final hematocrit of 50%