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Following its phosphorylation in vivo, Fingolimod is a potent agonist of sphingosine 1-phosphate receptors, however the non-phosphorylated pro-drug also exhibits non-selective inhibition of ceramide synthases as an off-target effect 29,30

(September 1996)

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It can be measured by connecting the 2H + /H 2 pair at pH 7 in the test cell to the SHE at pH 0)

Metabolic studies showed that AOD9604-treated animals had increased lipolytic rates measured in isolated adipocytes, elevated circulating free fatty acid levels, and enhanced fatty acid oxidation rates