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Under conditions of low cellular ATP utilization rates, ADP is maintained at low levels, resulting in accumulation of a high protein gradient across the inner membrane

Biochem Biophys Res Commun 423(4):763769 Fedorovskiy AG, Burakov AV, Terenin IM, Bykov DA, Lashkevich KA, Popenko VI, Makarova NE, Sorokin II, Sukhinina AP, Prassolov VS (2023) A solitary stalled 80S ribosome prevents mRNA recruitment to stress granules

doi: 10.1038/onc.2017.346 277 MettVKurnasovOVBespalovIAMolodtsovIBrackettCMBurdelyaLGet al

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Such ligands can be generated by evolution approaches and selecting from large combinatorial ligand libraries based on biological/genetic packages

Synbiotics alleviate the gut indole load and dysbiosis in chronic kidney disease