In addition, recent results from the ICARIA-MM trial showed that the ORR with daratumumab in combination with a PI, an IMiD, or an alkylating agent was similar in patients who had previously received isatuximab-Pd or Pd therapy (30.8 vs
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These include: Paraesthesia (pins and needles) in hands and feet Peripheral neuropathy with numbness or altered sensation Difficulty walking or balance problems (ataxia) Memory problems and cognitive difficulties Mood changes, including depression or irritability In severe cases, confusion or dementia-like symptoms Other manifestations may include: Loss of appetite and unintentional weight loss Constipation Visual disturbances (rare, but can occur with optic neuropathy) Important: The neurological complications of B12 deficiency can progress even in the absence of anaemia, making early detection crucial
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From a biochemical perspective, the peptides reported resistance to enzymatic degradation may be attributed to the presence of a disulfide bridge between cysteine residues, along with an N-terminal tyrosine substitution, which potentially supports its structural resilience under experimental conditions, such as in vitro digestion models
