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The promotion of T-cell-mediated tumour cytotoxicity has also been evidenced through the works of Di Biase [141]

When done professionally, side effects are minimal to none

PLoS One 10, e0133496

Protease-sensitive pro-antibodies whose Fc or Fab regions are masked until exposure to tumor-specific proteases could also restrict MDSC blockade to the malignant niche, reducing systemic toxicity (199)

To address these challenges, it is essential to develop ligand scaffolds incorporating bioorthogonal conjugation sites, such as azides or alkynes appropriate for copper-free click chemistry, that are positioned away from the coordination sphere

Key structural features include hydroxyl groups at positions 3, 3, and 4 on the phenyl ring and chromone nucleus, a methoxyl group at position 7 on the A ring, and a hydrogen atom at position 5