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Based on the fact that IR and IGF-1R are abundantly expressed in chondrocytes 27,28 and the previous work which showed upregulation of IR signaling in osteoblasts lacking IGF-1R, 12 we suspected that the increased proliferation of IR-deficient growth plate chondrocytes could be caused by upregulation of the IGF-1/IGF-1R signaling pathway

Nutr Cancer 2013

Getting your child comfortable with needles Children take their cues from their parents

For example, a study found a big jump in ejection fraction, a key heart health measure

Shiri AM, Fard-Aghaie M, Bedke T, Papazoglou ED, Sabihi M, Zazara DE, Zhang S, Lucke J, Seeger P, Evers M, et al

No therapeutic benefit was observed (Appendix Fig S4)