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Complementarily, the use of preclinical assays that are not based on specific mutations models should be considered, as for example the use of iPSCs from sALS and fALS patients (with or without specific mutations) that can be differentiated in MNs, astrocytes, and microglial cells [278] and represent a valuable tool for screening different compounds [279]

A variety of ferroptosis inducers can influence glutathione peroxidase directly or indirectly via diverse pathways, leading to decreased antioxidant capacity, accumulated cellular lipid peroxides, and finally inducing ferroptosis

doi: 10.1007/s11064-016-2011-0, 36

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N-acetyl-cysteine supplementation lowers high homocysteine plasma levels and increases glutathione synthesis in the transsulfuration pathway

Louis Internal Resources Join Us Contact Us People Divisions Patient Care Patient Care Find a Provider Locations Research Research Investigators Our Labs Publications Centers Resources Education Education Residency Fellowships Medical Student Education Pediatric Student Research Program (PSRP) News Giving Open Search David Perlmutter, MD