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One of the most common mechanisms of drug resistance is enhanced drug detoxification mediated by detoxifying enzymes such as glutathione S-transferases (GSTs), which can be exploited by malignant cells to increase survival through the acquisition of resistance to anticancer drugs (Coles and Ketterer 1990

Homocysteine accumulation in serum Decreased synthesis of cysteine (James) The interruption of the formation of glutathione by the described series of events at the present time has no single term describe the deleterious events that occur after inhibition of the methionine cycle

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10.1016/j.ijcard.2017.03.162 302 WanjareM.KawamuraM.HuC.AlcazarC.WangH.WooY

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