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Most of the studies reported the incidence of TIN using different cases and assessment tools, this hinders further research on the effect of these interventions on reducing the severity of neuropathy

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Zero-valent iron nanoparticles (ZVI-NP) can target and enhance the degradation of nuclear factor-E2-related factor 2 (NRF2), inducing ferroptosis in lung cancer cells through the Fenton reaction (with MDA levels increasing exponentially), while polarizing M2-type tumor-associated macrophages (TAMs) to M1-type and reducing the infiltration of regulatory T cells (Tregs) by half

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A small number of validated biomarkers are not unique to A-T, such as AFP and triglycerides

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