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NOX4 produces H 2 O 2 in the perinuclear region within thyroid cell, thus, when being in excess it can induce DNA damage, and also in such intracellular compartments as mitochondria and endoplasmic reticulum [139] (see also Fig

Safety profiles vary significantly : IV administration carries serious risks including anaphylaxis, hepatotoxicity, and potential endotoxin contamination, while oral supplements typically cause only mild gastrointestinal effects like flatulence or loose stools

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The effect of SIRT1 and SIRT3 on FoxOs A family of SIRT targets are class O mammalian forkhead transcription factors (FoxO1, FoxO3, FoxO4 and FoxO6) which participate in regulating oxidative stress