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Remarkably, the combination of PHA, SE with AST showed the most prominent anti-inflammatory effects compared to any other group in this study

J.ClaphamD

Transl Sports Med 2022:9065923

452 These STAT1 heterodimers bind to IRF1 to form a complex, 473 which then translocates to the nucleus and binds to the IRF1 response element (IRE), modulating the transcription of PD-L1 genes and upregulating PD-L1 expression