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Association of glutathione S-transferases M1, P1 and T1 variations and risk of late-onset Alzheimer's disease

For thiopurines, the complex biotransformation pathway of azathioprine and 6-mercaptopurine is implicated and the association between TPMT gene alleles and the metabolism rate was significant and was approved by the FDA as the first main pharmacogenetic biomarker [37]

22 Meanwhile, a reduced percentage of eosinophils, basophils, and monocytes was observed in severe patients

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