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In addition, lipid A (ligand of TLR2), poly (I:C), and lipopolysaccharides can activate MAP4K2 (Zhong and Kyriakis, 2004), which can further activate MAPK and the Hippo pathway, indicating that the TLR ligands may interact with the Hippo pathway through MAPK

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Many sites of mitochondria serve as potential targets for mitochondrial therapy, including respiratory chain, oxidation and antioxidation, mitochondrial dynamics, and so on

Therefore, accurately targeting tumor cells while sparing immune cells in the TME is crucial for the application of ferroptosis in cancer therapy

The abnormal calcium signaling seen in AD further accelerates neuronal dysfunction and synaptic loss, particularly in brain regions critical for memory and learning (Zndorf and Reiser, 2011)

Their placebo group showed significant increase in dopaminergic medication and clinical improvements (161)