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Riboflavin has therapeutic potential for certain mitochondrial disorders, such as mutations in the X-linked apoptosis-inducing factor mitochondria-associated 1 (AIFM1) and mitochondrial complex I deficiency nuclear type 20 or mitochondrial complex II deficiency (, )

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10.3389/fendo.2021.791071 [DOI] [PMC free article] [PubMed] [Google Scholar] Coticchio G., Lagalla C., Sturmey R., Pennetta F., Borini A

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In general, fruit and vegetable intake showed a consistently positive association with better motility and morphology [98, 99]

Oxidative metabolism signatures predict response to 5FU-based chemotherapy treatment Given this robust adaptation to facilitate cellular survival in cancer cells treated with 5FU, we next postulated that elevated mitochondrial metabolism may be a predictor of response to 5FU-based chemotherapy