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many different animal species are studied in the laboratory, including terrestrial (land), aquatic (water), and microscopic animals Arrhythmia - abnormal heart rhythm Atria (singular: atrium) - the two upper chambers of the heart that receive blood from the veins and contract to force blood into the ventricles Ischemia (adjective: ischemic) - inadequate blood supply to an organ or tissue Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Placebo - a chemically inactive substance Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Test tube - a research experiment performed in a test tube, culture dish, or other artificial environment outside of a living organism

10.1111/j.1528-1167.2008.01821.x 23

May Contain (+/-): Titanium Dioxide (CI 77891), Iron Oxides (CI 77491, CI 77499, CI 77492), Blue 1 Lake (9CI 42090), Red 7 Lake (CI 15850), Yellow 5 Lake (CI 19140), Red 6 (CI 15850), Red 28 Lake (CI 45410), Manganese Violet (CI 77742)

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Accessed January 19, 2026

doi: 10.1093/rheumatology/kez378 63 NarasimhanRCorasRRosenthalSBSweeneySRLodiATizianiSet al