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Structureel valt de keten vooral op door het hoge aandeel proline: vier van de vijftien posities zijn prolineresiduen, waarvan drie direct op elkaar volgen

A researcher who miscalculates concentration by a factor of two administers double the intended dose across an entire study, invalidating weeks of data collection

- when there is risk of torsades de pointes, for example in patients with prolonged QT, concomitant administration of other medications that produce torsades de pointes (amiodarone, quinidine, bepridil, IV erythromycin, halofrantine, pentamidine, sparfloxacin, sultopride, vincamine, betrilio, disopyramide, sotalol, etc)

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Position: upright, with the stopper clean and intact