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Interestingly, plasma concentrations of the indoles synthesized from TRP, I3AA, and I3PA, were found to be significantly increased in the MDD patients in this study after the SSRI treatment

Shi J, Liu Y, Yan S, Yan D

In conclusion, esculetin and esculin both have antioxidant and anti-inflammatory effects, and may be used for the treatment or improvement of various diseases in the future