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Patients in the probiotic arm of the study showed a statistically significant reduction in the expression of the IGF-1, a statistically significant increase in the FOXO1 gene, which mediates inhibitor action on insulin and IGF-1, and an improvement in acne

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Furthermore, curcumin stimulates bile secretion, which can worsen conditions like gallstones or bile duct obstruction

SGLT2 inhibitor empagliflozin ameliorates tubulointerstitial fibrosis in DKD by downregulating renal tubular PKM2