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Carbonylation of the p46 and p54 isoforms of JNK kinase in human hepatic stellate cells activates activator protein 1 (AP-1), which stimulates the expression of procollagen type I, a fundamental step in liver fibrosis (83)

Collectively, these OFF-to-ON switching strategies illustrate therapeutic approaches in which GSH acts as a biological trigger for selective activation of cytotoxic agents in the GSH-rich tumor microenvironment

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380,381 Hypercytokinemia induced by Th-17 was identified as an initial host response in severe cases of H1N1 infection in 2009

Adipose tissue depot-specific differences in adipocyte apolipoprotein E expression