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A 2025 EMJ Dermatology scoping review reached the same conclusion: low-molecular-weight HA penetrates the dermis while high-molecular-weight HA delivers surface hydration and barrier protection

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PI3K/Akt/mTOR Signaling Cascade A primary downstream pathway of IGF-1R activation is the PI3K/Akt/mTOR cascade, which regulates cell survival, protein synthesis, and metabolic homeostasis

L., Lefebvre, S

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A., Hearon, C