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THE FIT PROGRAM INCLUDED ADULT PATIENTS WITH CHRONIC ITP WHO HAD RECEIVED 1 PRIOR THERAPY FIT program patients were representative of the general adult chronic ITP population, including exposure to prior therapies TAVALISSE dosing 3 Starting dose of TAVALISSE: One 100 mg tablet BID Based on platelet count and tolerability, the dose could be increased to one 150 mg tablet BID at or after week 4 Patients who had a platelet count 50 x 10 9 /L at the time of rollover to the FIT-3 open-label extension study maintained their existing dose of TAVALISSE References: 1

2,21 Calcified plaque is generally more stable than non-calcified plaque

These mechanisms contribute to the alleviation of diabetes-associated dementia (Ha et al

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to the cell surface ( The toxic effects of cadmium are significantly negative on growth, metamorphic development, and stress responses in amphibian larvae

The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration