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Research confirmed an estimated half-life of 5.88.1 days in healthy adults

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Small 6 , 537544 (2010)

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Varney and Clark were good friends and Clark took inspiration for his role from his late pal

Hence, functional vitamin B12 is required to raise levels of S-Adenosylmethionine (SAM), but SAM in turn is required for activation of the B6-dependent enzyme CBS, which is involved in converting homocysteine to cystathionine