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The NRAMPs might be a possible candidate

A prospective cohort study involving 266 elderly adults treated with epithalamin (the parent compound from which Epithalon was derived) over 2-3 years with subsequent 4-5 year follow-up demonstrated mortality reduction of 28% overall, with a 2-fold decrease in cardiovascular disease-specific mortality

(3) Reducing placebo response rates by employing central reading to achieve statistical significance

Yeli F, Xinyu W, Ge Y, Hongfang G, Min Y