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GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, and GPX8 associate with chloroplastic glutathione reductase proteins and mitochondrial glutathione transferases (DHAR2) related to the glutathione metabolic process ( Figure 5 )

Because a major physiologic function of GSH is to provide cells with a reducing environment and to destroy the reactive oxygen compounds and free radicals formed in metabolism, organs that have low concentrations of other antioxidants (such as catalase and superoxide dismutase) are thought to be more dependent on GSH for detoxification of reactive oxygen species than are organs that have alternative antioxidants

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Most preterm infants who develop BPD are in the cannalicular to saccular stage of lung development

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