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However, mutant variants such as A53T bind to the lysosomal receptor LAMP2A but fail to translocate into the lumen, resulting in a blockage that impairs not only their own degradation but also that of other CMA substrates [171, 172]

Biochem J 287(3):957963 Perperopoulou F, Pouliou F, Labrou NE (2018) Recent advances in protein engineering and biotechnological applications of glutathione transferases

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