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Keep pens away from the refrigerator door, where temperature fluctuations are greatest

This oxidative burden damages neuronal membranes and mitochondrial DNA, impairing energy supply and synaptic plasticity (113)

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The drug Rapamycin is used for autophagy but has side-effects, whereas, TCM promotes autophagy via AMPK, mTOR, and PI3K/Akt to protect -cells [274, 275]