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These agents are well-known for their anticholinergic effects, to which cirrhotic patients may be more susceptible

Immunohistochemical evaluation of oxidative stress markers in chronic hepatitis C

While early research provided a strong foundation, it was largely exploratory and not designed for risk assessment applications

However, this model was challenged by several other studies and it is now widely accepted that FXN functions primarily in Fe-S cluster biosynthesis, with iron accumulation, heme deficiency and oxidative stress sensitivity appearing later on as secondary defects

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Notably, p21 levels were increased in the GST 4QN -p53-expressing cells compared to the untreated cells (Fig