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Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025

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Calcium imaging Brain slices were prepared from adult NMRI male mice (aged 1828 days)

In glioblastoma multiforme, the combination of artesunate with lower doses of metformin demonstrates antitumor effects by activating the AMPK/mTOR pathway and inducing autophagy in human glioblastoma (U251 and U118-MG) cells [180]

[DOI] [PubMed] [Google Scholar] 37.Mozaffari HR, Ramezani M, Janbakhsh A, Sadeghi M