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Reliability and reproducibility of metabolite quantification using 1 H MRS in the human brain at 3 T and 7 T

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Silico docking (Schrodinger Inc., Small-Molecule Drug Discovery Suite, 2016-1) revealed that benserazide binds to the active site of CBS (PDB ID: 1JBQ) and reacts with the PLP cofactor to form a reversible but kinetically stable Schiff base, and its trihydroxybenzyl ring can form hydrogen bonds with polar residues located in the peripheral cavity (such as His203, Tyr223, and Tyr308), resulting in strong inhibition