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The inhibition of these potassium channels leads to the opening of voltage-dependent calcium channels (L-type), resulting in an increase in intracellular calcium ions, which triggers the release of insulin

In most polyploid plants, segmental duplication occurs frequently [37]

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Wistar albino rats (pre-treated with methotrexate to produce folate deficiency similar to in humans exposed to methanol) then exposed to aspartame (40 mg/kg) showed a marked increase in the TNF gene expression and a decrease in NF-B gene expression in the liver relative to the liver of unexposed study controls ( P 0.05) (Rahiman and Pool, 2014)