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Acknowledgements This study was funded by Hualien Tzu Chi Hospital with Grant Number TCRD 108-36

We finally established a model where a yeast strain lacking 5-oxoprolinase ( oxp1 strain) was treated with excess 5-OP in the medium

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Khoury HJ, Garcia-Manero G, Borthakur G , Kadia T, Foudray MC, Arellano M, Langston A, Bethelmie-Bryan B, Rush S, Litwiler K, Karan S, Simmons H, Marcus AI, Ptaszynski M, Kantarjian H