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Indeed, while immune dysfunction is evident across all stages of psychosis-spectrum disorders [54], an exacerbated inflammatory cascade characterized by elevated proinflammatory cytokine production has been found as independent of antipsychotic medication and present in both first episode (IL-12, IFN-, TNF-, and sIL-2R) and acutely relapsed phase (IL-1, IL-6, and TGF-) of psychotic patients [55], while a recent meta-analysis has reported that proinflammatory cytokines (mainly IFN-, IL-6 and IL-12) are significantly elevated in drug nave FEP populations and associated with presenting negative symptomatology [56]

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and GPx, GST and TrxR enzymes activity in the liver (Figures 4HJ, 5K), as well as GST activity in serum (Figure 5J) in golden hamsters, fed a high-fat diet

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However, the inclusion of subjective determinations is a disadvantage of the aforementioned semiquantitative scoring system

doi: 10.4161/onci.26246