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systemically examined the expression of GPxs in breast cancer cell lines and found that GPx5 and GPx7 were down-regulated in the human breast cancer MCF-7 and MDA-MB-231 cell lines and GPx6 was also down-regulated in MDA-MB-231cells compared with healthy breast MCF-10A cells [19]

In mouse models, copper deficiency impairs cardiac function, manifesting as reduced diastolic and systolic performance alongside a diminished inotropic response to beta-adrenergic stimulation, which compromises the heart's ability to adapt to stress [206]

10.1038/nm.2536 21 D'ArcyP.WangX.LinderS

After a delay of 0 to 2 days, all patients experienced a rapid 1 st HDV decline phase (median slope of 0.14 log/day [IQR:0.06]), followed by a viral plateau (flat-partial response, FPR, n=8

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