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Depletion of Brain Glutathione by Buthionine Sulfoximine Enhances Cerebral Ischemic Injury in Rats

In late-onset AD, which occurs sporadically after the age of 65, the impairment of amyloid -protein (A) clearance mechanisms seems to be a primary factor in the accumulation of A in the brain (Mawuenyega et al., 2010)