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This structural remodeling impairs synaptic signaling by weakening excitatory postsynaptic potentials, partly due to the disruption of neurotransmitter systems, including serotonin (5-HT) and hypocretin (orexin), which are critical for maintaining synaptic strength (97, 107)

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The in ovo supplementation of bioactive substances can provide nutrients not only for energy reserve to support early life but also to improve the development of the intestinal mucosa and its barrier components

Second, in subsequent blogs, we present some of the key mechanisms by which nutrition can affect the epigenome, with a particular focus on the role of one-carbon ( 1-C ) metabolism, specifically folate and DNA methylation