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doi: 10.1126/science.aal3321 123 GrahamESAngelCESchwarczLEDunbarPRGlassM

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14 NAD + biosynthesis De novo pathway Mammalian cells can generate NAD + de novo from dietary tryptophan (Trp) by the kynurenine pathway (KP), which is initialized by either TDO or IDO